Lenvatinib

A potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively.1 Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively.1 Suppresses lymph node and lung metastasis in human mammary breast tumor model.2 Suppresses tumor cell migration and invasion.3 Inhibits angiogenesis.4