2-AAPA

Inhibits glutathione reductase and thioredoxin reductase, IC50s=6.7 and 8.7 µM respectively, and impairs mitochondrial function.1 May be used to induce a cellular model of thiol oxidative stress.2 Enhances sensitivity of cancer cell lines to X-ray irradiation.3 Induces G2/M cell cycle arrest by inducing thiol oxidative stress resulting in α-tubulin S-glutathionylation-mediated microtubule depolymerization.4 Improves limb revascularization by glutathionylation and subsequent stabilization of HIF-1α.5