Leu-Leu-OMe HBr
Product Specifications
Background
Leu-Leu-OMe is a lysosomal damaging agent (lysosomotropic) . It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4 LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes1. Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant5. Induces lysophagy.4
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Available Sizes
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