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Leelamine HCl

Product Specifications

Background

A lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1 Induces apoptosis in breast cancer2, melanoma3 and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5 Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.6

Conjugation

Unconjugated

Buffer

Off-white or beige solid

Storage Conditions

-20°C

Available Sizes

Frequently Asked Questions

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