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Pomalidomide

Product Specifications

Background

Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5

Conjugation

Unconjugated

Buffer

Yellow solid

Storage Conditions

-20°C

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-82578C

Available Sizes

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