Gambogic acid
Product Specifications
Background
Induces apoptosis in a variety of cell lines acting as an antagonist of Bcl-2 family proteins (IC50 < 1 μM) 1, however additional targets may contribute to its cytotoxicity. It suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition.2 Potentiates the chemosensitivity of cancer cells to other agents.3 Down-regulates surviving, reversing docetaxel resistance in cancer cells.4
Conjugation
Unconjugated
Buffer
Orange solid
Storage Conditions
-20°C
Available Sizes
Curated Selection
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