Vatalanib 2HCl

Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM) 1. Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 µM) . Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 µM) . Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.