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GW-2580

Product Specifications

Background

Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM) 1. Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.

Conjugation

Unconjugated

Buffer

Off-white solid

Storage Conditions

RT

Available Sizes

Frequently Asked Questions

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