Myriocin (ISP-1)
Product Specifications
Background
Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C
Available Sizes
Frequently Asked Questions
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