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Mithramycin A

Product Specifications

Background

Inhibits DNA methyl transferase1. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibitings their expression2. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis3.

Conjugation

Unconjugated

Buffer

Yellow solid

Storage Conditions

-20°C

Available Sizes

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