What is the catalog number for ML323?

The catalog number for ML323 is bs-82320C.

What sizes are available for ML323?

ML323 is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does ML323 come in?

ML323 is available in 2 different pack sizes.

ML323 is currently made to order / not held in immediate stock. Contact us for lead time.

ML323

Product Specifications

Background

Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 M.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2 ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3