What is the catalog number for UNC-2170 HCl?

The catalog number for UNC-2170 HCl is bs-82319C.

What sizes are available for UNC-2170 HCl?

UNC-2170 HCl is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does UNC-2170 HCl come in?

UNC-2170 HCl is available in 2 different pack sizes.

Is UNC-2170 HCl in stock?

UNC-2170 HCl is currently made to order / not held in immediate stock. Contact us for lead time.

UNC-2170 HCl

Product Specifications

Background

The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1