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UCF-101

Product Specifications

Background

UCF-101 is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 μM for His-Omi134-458) . Shows very little activity against various other serine proteases tested (IC50 ≥ 200 μM) .1 Mitigates streptozotocin-induced cardiomyocyte dysfunction.2 Protects against cerebral oxidative injury and cognitive impairment in a rat model.3 Cell permeable.

Conjugation

Unconjugated

Buffer

Orange solid

Storage Conditions

-20°C

Available Sizes

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