WEB-2086

Potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM) 1. Displays an activity profile which includes antiinflamatory, antiangiogenesis and anticancer activity2. Along with leukotriene antagonists, cooperatively provides a robust anti-inflammatory effect regulating PMNL migration and edema formation3. Displays analgesic effects in animal models of neuropathic pain4. Active in vivo.