What is the catalog number for JQ1 (+/-)?

The catalog number for JQ1 (+/-) is bs-82200C.

What sizes are available for JQ1 (+/-)?

JQ1 (+/-) is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does JQ1 (+/-) come in?

JQ1 (+/-) is available in 2 different pack sizes.

Is JQ1 (+/-) in stock?

JQ1 (+/-) is currently made to order / not held in immediate stock. Contact us for lead time.

JQ1 (+/-)

Product Specifications

Background

JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N) ), BRD4 (C-terminal (C) ), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.