AG-490
Product Specifications
Background
A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.
Conjugation
Unconjugated
Buffer
Tan solid
Storage Conditions
-20°C
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-82062C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS147006-01 0.005 mg
Mouse Anti Human Minichromosome Maintenance Complex Component 7
Ask
View Details MBS147006-02 0.02 mg
Mouse Anti Human Minichromosome Maintenance Complex Component 7
Ask
View Details 
MBS147006-03 0.1 mg
Mouse Anti Human Minichromosome Maintenance Complex Component 7
Ask
View Details 
MBS147006-04 5x 0.1 mg
Mouse Anti Human Minichromosome Maintenance Complex Component 7
Ask
View Details