What is the catalog number for AG-490?

The catalog number for AG-490 is bs-82062C.

What sizes are available for AG-490?

AG-490 is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does AG-490 come in?

AG-490 is available in 2 different pack sizes.

AG-490 is currently made to order / not held in immediate stock. Contact us for lead time.

AG-490

Product Specifications

Background

A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.