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GW-5074

Product Specifications

Background

Potent inhibitor of cRAF1 kinase (IC50 = 9 nM) . Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects In vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

Conjugation

Unconjugated

Buffer

Dark orange solid MP = 267-268°C

Storage Conditions

-20°C

Available Sizes

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