SIS17
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1].
Product Specifications
CAS Number
2374313-54-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sis17.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC
Molecular Formula
C21H38N2OS
Molecular Weight
366.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14 (7) :1393-1397.|[2]Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36 (7) :e22326.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC11
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
023857 96 Tests
Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) BioAssayTM ELISA Kit (Mouse)
Sign In for Pricing
View Details 