SIS17
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1].
Product Specifications
CAS Number
2374313-54-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sis17.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC
Molecular Formula
C21H38N2OS
Molecular Weight
366.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14 (7) :1393-1397.|[2]Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36 (7) :e22326.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC11
Available Sizes
Frequently Asked Questions
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