VRK1/CK1-IN-1

VRK1/CK1-IN-1 (compound 36) is a dual inhibitor of vaccinia-related kinase 1 (VRK1) and casein kinase 1 (CK1), with the Ki of 37.9 nM for VRK1 and IC50s of 17 nM and 15 nM for δ and ε isoforms of CK1, respectively[1].

Product Specifications

CAS Number

[3050772-20-5]

UNSPSC

12352005

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vrk1-ck1-in-1.html

Purity

98.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(CC2=CC(C)=NO2)C3=CN=C(NC4=CC(F)=C(O)C(F)=C4)N=C3N(C)[C@H]1C

Molecular Formula

C19H18F2N6O3

Molecular Weight

416.38

References & Citations

[1]Fernando H de Souza Gama, et al. Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε. J Med Chem. 2024 May 23.