ADAMTS13 Antibody
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF) -cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
Product Specifications
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
Q76LX8
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 829-858 from the human protein was used as the immunogen for this ADAMTS13 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Limitations
This ADAMTS13 antibody is available for research use only.
Storage Conditions
Aliquot the ADAMTS13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ADAMTS13 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
IHC analysis of FFPE human hepatocarcinoma with ADAMTS13 antibody
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