CD130 Antibody / IL6ST / Interleukin 6 Receptor subunit beta
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM) . This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
Product Specifications
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:25
UniProt
P40189
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 871-899 from the human protein were used as the immunogen for the CD130 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Purified
Limitations
This CD130 antibody is available for research use only.
Storage Conditions
Aliquot the CD130 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Frequently Asked Questions
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