Dishevelled Antibody / DVL1
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Product Specifications
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:25-1:50, Immunofluorescence: 1:25
UniProt
O14640
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 442-470 from the human protein were used as the immunogen for the Dishevelled antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, IHC-P
Purity
Antigen affinity purified
Format
Purified
Limitations
This Dishevelled antibody is available for research use only.
Storage Conditions
Aliquot the Dishevelled antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasmic
Image Legend
Western blot testing of human 1) K562, 2) MDA-MB-453, 3) PC-3 and 4) kidney lysate with Dishevelled antibody. Predicted molecular weight ~75 kDa.
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