LH1 Antibody / PLOD1
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity.
Product Specifications
Specifications
Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:10-1:5, Flow cytometry: 1:25 (1x10e6 cells)
UniProt
Q02809
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 66-94 from the human protein were used as the immunogen for the LH1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Purified
Limitations
This LH1 antibody is available for research use only.
Storage Conditions
Aliquot the LH1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of human 1) A431, 2) MCF7, 3) U-2 OS and 4) U-87 MG cell lysate with LH1 antibody. Predicted molecular weight ~83 kDa.
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