FOLR2 Antibody / Folate Receptor beta

FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.

Product Specifications

Specifications

Western blot: 1:1000, Immunohistochemistry (FFPE) : 1:25-1:50

UniProt

P14207

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 18-46 from the human protein were used as the immunogen for the FOLR2 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IHC-P, FACS

Purity

Antigen affinity purified

Format

Purified

Limitations

This FOLR2 antibody is available for research use only.

Storage Conditions

Aliquot the FOLR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the FOLR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.