FOLR2 Antibody / Folate Receptor beta
FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
Product Specifications
Specifications
Western blot: 1:1000, Immunohistochemistry (FFPE) : 1:25-1:50
UniProt
P14207
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 18-46 from the human protein were used as the immunogen for the FOLR2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Purified
Limitations
This FOLR2 antibody is available for research use only.
Storage Conditions
Aliquot the FOLR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of human 1) KG-1, 2) MCF7 and 3) MDA-MB-453 cell lysate with FOLR2 antibody. Predicted molecular weight ~29 kDa.
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