MMP10 Antibody| Matrix metalloproteinase 10
MMP10 belongs to the matrix metalloproteinase family, a group of enzymes that play a key role in tissue remodeling by degrading various components of the extracellular matrix. Specifically, MMP10 is known for its ability to degrade collagen, a major structural component of connective tissue. By breaking down collagen, MMP10 helps to facilitate the turnover of damaged tissues and promote the regeneration of new, healthy tissue. One of the most intriguing aspects of MMP10 is its regulation in response to different stimuli. For example, MMP10 expression can be induced by factors such as growth factors, cytokines, and mechanical stress. This dynamic regulation allows MMP10 to respond to changing environmental conditions and play a crucial role in processes such as tissue repair and inflammation. Research has also shown that dysregulation of MMP10 activity can have detrimental effects on tissue homeostasis. For example, overexpression of MMP10 has been linked to various pathological conditions, including cancer metastasis and inflammatory diseases. On the other hand, decreased MMP10 activity has been associated with impaired wound healing and fibrosis.
Product Specifications
Specifications
Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100, Immunofluorescence: 1:50-1:100
UniProt
P09238
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 380-410 from the human protein was used as the immunogen for the MMP10 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, IF
Format
Purified
Limitations
This MMP10 antibody is available for research use only.
Storage Conditions
Store the MMP10 antibody at -20°C.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide and 50% glycerol
Applications Notes
Titration of the MMP10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human A549 cell lysate with MMP10 antibody. Predicted molecular weight ~54 kDa.
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