CrkRS Antibody / CDK12 / Cyclin-dependent kinase 12
CrkRS, also known as Cdc2-related kinase, arginine/serine-rich, CDK12 and Cyclin-dependent kinase 12, is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. It also regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.
Product Specifications
Specifications
Western blot: 1:500-1:1000
UniProt
Q9NYV4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 1-30 from the human protein was used as the immunogen for this CrkRS antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Format
Purified
Limitations
This CrkRS antibody is available for research use only.
Storage Conditions
Aliquot the CrkRS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
http://www.nsjbio.com/tds-pdf/crkrs-antibody-cdk12-cyclin-dependent-kinase-12-f55075
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CrkRS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of mouse liver tissue lysate with CrkRS antibody. Predicted molecular weight ~164 kDa.
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