HLA-B Antibody
One of the key roles of the HLA-B protein (HLA class I histocompatibility antigen, B alpha chain) is to present fragments of proteins from foreign invaders to our immune cells, specifically T cells. This process, known as antigen presentation, allows our immune system to recognize and target these invaders for destruction. Without a properly functioning HLA-B protein, our immune system would struggle to effectively identify and combat threats. In addition to its role in immune response, HLA-B has also been linked to a variety of health conditions. Certain variations of the HLA-B gene have been associated with an increased risk of autoimmune diseases, such as rheumatoid arthritis and psoriasis. Understanding these genetic factors can help researchers develop personalized treatments that target the underlying causes of these conditions.
Product Specifications
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:25 per million cells in 0.1ML
UniProt
P03989
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 62-90 from the human protein were used as the immunogen for the HLA-B antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Purified
Limitations
This HLA-B antibody is available for research use only.
Storage Conditions
Aliquot the HLA-B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
IHC testing of FFPE human tonsil tissue with HLA-B antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
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