PFKL Antibody / ATP-PFK / ATP-dependent 6-phosphofructokinase liver type
The PFKL protein is an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, a key step in the glycolytic pathway. It also plays a role in regulating glucose metabolism, which is crucial for maintaining healthy blood sugar levels. Dysregulation of the PFKL protein has been linked to metabolic disorders such as diabetes and obesity. While it is primarily found in the liver, where it helps regulate glucose production, it is also found in other tissues such as skeletal muscle and adipose tissue.
Product Specifications
Specifications
Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100
UniProt
P17858
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 669-699 from the human protein was used as the immunogen for the PFKL antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Format
Purified
Limitations
This PFKL antibody is available for research use only.
Storage Conditions
Aliquot the PFKL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasm
Image Legend
IHC staining of FFPE human cancer tissue with PFKL antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
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