MAPE Antibody / PRAME
MAPE (Melanoma antigen preferentially expressed in tumors), also called PRAME (Preferentially expressed antigen of melanoma), is a protein that is preferentially expressed in tumors, particularly in melanoma. It plays a vital role in regulating cell proliferation, migration, and invasion, making it a promising target for therapeutic interventions. Studies have shown that the overexpression of MAPE protein is associated with aggressive melanoma subtypes, indicating its potential as a prognostic biomarker in melanoma patients.
Product Specifications
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:25 per million cells in 0.1ml
UniProt
P78395
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 476-502 from the human protein was used as the immunogen for the MAPE antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS
Purity
Antigen affinity
Format
Purified
Limitations
This MAPE antibody is available for research use only.
Storage Conditions
Aliquot the MAPE antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasm, Nucleus, Cell Membrane
Image Legend
IHC staining of FFPE human testis tissue with MAPE antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
HYAL3 (Hyaluronidase 3, Hyaluronidase-3, Hyal-3, Hyaluronoglucosaminidase-3, Lung Carcinoma Protein 3, LuCa-3, LUCA3) (MaxLight 650)
Lentiviral mouse 2810408A11Rik shRNA (UAS) - Lentiviral mouse 2810408A11Rik shRNA (UAS, iRFP) plasmid
