TIAM1 Antibody / T cell lymphoma invasion and metastasis 1
TIAM1 is a protein that plays a crucial role in cell migration and invasion. In T cell lymphoma, increased expression of TIAM1 has been associated with enhanced invasive capabilities of cancer cells. TIAM1 promotes the formation of invasive structures called invadopodia, which facilitate cancer cell movement through tissues. Additionally, TIAM1 has been shown to activate signaling pathways that promote metastasis, making it a key player in the spread of T cell lymphoma. Studies have demonstrated that targeting TIAM1 can inhibit T cell lymphoma invasion. By disrupting the activity of TIAM1, researchers have been able to reduce the ability of cancer cells to invade surrounding tissues. This suggests that TIAM1 could be a potential therapeutic target for inhibiting T cell lymphoma invasion and slowing down disease progression. Metastasis is a major concern in T cell lymphoma, as cancer cells can spread to distant organs and tissues, leading to poor prognosis. TIAM1 has been implicated in promoting the metastatic spread of T cell lymphoma cells. By targeting TIAM1, researchers have observed a decrease in the ability of cancer cells to metastasize, highlighting the potential of TIAM1 as a therapeutic target for preventing T cell lymphoma metastasis.
Product Specifications
Specifications
Western blot: 1:1000-1:2000
UniProt
Q13009
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1478-1506 from the human protein was used as the immunogen for the TIAM1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Purified
Limitations
This TIAM1 antibody is available for research use only.
Storage Conditions
Aliquot the TIAM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of human 1) Ramos, 2) HCT-116 and 3) RPM1 8226 cell lysate with TIAM1 antibody. Expected molecular weight ~178 kDa.
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