KCNT1 Antibody / Slo2.2

KCNT1 protein plays a crucial role in regulating the electrical activity of neurons in the brain. Mutations in the KCNT1 gene have been linked to a rare form of epilepsy known as KCNT1-related epilepsy, as well as other neurological conditions such as intellectual disability and developmental delays. Recent studies have also found that this protein may play a role in other diseases, such as autism, schizophrenia, and even certain types of cancer.

Product Specifications

Specifications

Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100

UniProt

Q5JUK3

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1035-1061 from the human protein was used as the immunogen for the KCNT1 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IHC-P

Format

Purified

Limitations

This KCNT1 antibody is available for research use only.

Storage Conditions

Store the KCNT1 antibody at -20°C.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide and 50% glycerol

Applications Notes

The stated application concentrations are suggested starting points. Titration of the KCNT1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

IHC staining of FFPE human brain tissue with KCNT1 antibody (left) and negative control (right) . HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.