RSPO2 Antibody / R-spondin-2

RSPO2 is a member of the R-spondin family of proteins, which are known for their ability to regulate the Wnt signaling pathway. This pathway plays a crucial role in cell proliferation, differentiation, and stem cell maintenance. RSPO2 specifically has been shown to enhance Wnt signaling, leading to increased cell growth and tissue regeneration. Research on RSPO2 is still in its early stages, but some studies have already shown promising results. For example, a study published in the journal Cell Stem Cell found that RSPO2 can enhance the regenerative capacity of intestinal stem cells, potentially leading to new treatments for diseases like inflammatory bowel disease.

Product Specifications

Specifications

Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:10-1:50 per million cells in 0.1ml

UniProt

Q6UXX9

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 190-218 from the human protein was used as the immunogen for this RSPO2 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IHC-P, FACS

Purity

Antigen affinity

Format

Antigen affinity purified

Limitations

This RSPO2 antibody is available for research use only.

Storage Conditions

Store at 4°C for up to one month. For long term, aliquot the RSPO2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the RSPO2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

IHC staining of FFPE human lung carcinoma tissue with RSPO2 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.