ERVW-1 Antibody / Syncytin-1

ERVW-1 is also known as ERVWE1 and Syncytin-1. The human ERVWE1 locus is derived from a human endogenous retrovirus-W (HERV-W) provirus located on chromosome 7. This provirus has inactivating mutations in the gag and pol genes, but the envelope glycoprotein gene has been selectively preserved. The product of this gene, syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

Product Specifications

Specifications

Western blot: 0.5-1 µg/mL

UniProt

Q9UQF0

Host

Rabbit

Reactivity

Human

Immunogen

Amino acids YYVNQSGIVTEKVKEIRDRIQRRAEELRNT of human ERVW-1 were used as the immunogen for the ERVW-1 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Limitations

This ERVW-1 antibody is available for research use only.

Storage Conditions

After reconstitution, the ERVW-1 antibody antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the ERVW-1 antibody should be determined by the researcher.

Image Legend

Western blot testing of human 1) HeLa, 2) K562, 3) SH-SY5Y and 4) MCF7 cell lysate with ERVW-1 antibody. Predicted molecular weight: 60~80 kDa depending on glycosylation level.