TIA1 Antibody / T-Cell Intracellular Antigen-1
T-Cell Intracellular Antigen-1 (TIA1) is involved in regulating gene expression and has been found to be essential for the maintenance of T-cell homeostasis. Research has shown that TIA1 is involved in alternative splicing and mRNA degradation, processes that are essential for the proper functioning of T-cells. In addition, TIA1 has been shown to play a role in the regulation of immune responses and inflammation. TIA1 also plays a role in the response to stress. When T-cells are exposed to stress, TIA1 relocalizes to stress granules and helps to regulate the translation of stress-induced mRNAs. This process is essential for the survival of T-cells under stress conditions.
Product Specifications
Specifications
Western blot: 0.1-0.3 µg/mL, Immunohistochemistry (FFPE) : 3.75 µg/mL, Immunofluorescence: 5 µg/mL, ELISA (peptide) LOD: 1:128000
UniProt
P31483
Host
Goat
Reactivity
Human
Immunogen
Amino acids PKSTYESNTKQ were used as the immunogen for this TIA1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, IF, ELISA (peptide)
Purity
Antigen affinity
Format
Antigen affinity purified
Limitations
This TIA1 antibody is available for research use only.
Storage Conditions
Aliquot and store the TIA1 antibody at -20°C.
Formulation
0.5 mg/mL in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide
Applications Notes
Optimal dilution of the TIA1 antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
Immunofluorescent staining of fixed and permeabilized human HeLa cells with TIA1 antibody (green) at 5ug/ml and DAPI nuclear stain (blue) .
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