ABCA4 Antibody / ATP-binding cassette sub-family A member 4
The ABCA4 protein is a transporter molecule responsible for moving retinal molecules across cell membranes in the eye and may have a broader impact on neurological processes. Research has shown that this protein is not restricted to the eyes, but is also present in various regions of the brain. ABCA4 plays a role in the maintenance of lipid homeostasis in the central nervous system. Lipids are essential components of cell membranes and are crucial for neuronal function. Disruptions in lipid metabolism have been implicated in numerous neurological disorders, including Alzheimer's disease and Parkinson's disease. ABCA4 has been found to interact with other proteins involved in synaptic transmission and neuronal signaling. This suggests that the protein may play a role in modulating communication between neurons, which is essential for cognitive function.
Product Specifications
Specifications
Immunofluorescence: 10 µg/mL, ELISA (peptide) LOD: 1:128000
UniProt
P16284
Host
Goat
Reactivity
Human, Mouse
Immunogen
Amino acids KQQTESHDLPLHPR were used as the immunogen for this ABCA4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, ELISA (peptide)
Purity
Antigen affinity
Format
Antigen affinity purified
Limitations
This ABCA4 antibody is available for research use only.
Storage Conditions
Aliquot and store the ABCA4 antibody at -20°C.
Formulation
0.5 mg/mL in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide
Applications Notes
Optimal dilution of the ABCA4 antibody should be determined by the researcher.
Location
Membrane, ER, Cytoplasmic vesicles
Image Legend
Immunofluorescent staining of fixed and permeabilized human HeLa cells with ABCA4 antibody (green) at 10ug/ml and DAPI nuclear stain (blue) .
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items