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ABCA4 Antibody / ATP-binding cassette sub-family A member 4

The ABCA4 protein is a transporter molecule responsible for moving retinal molecules across cell membranes in the eye and may have a broader impact on neurological processes. Research has shown that this protein is not restricted to the eyes, but is also present in various regions of the brain. ABCA4 plays a role in the maintenance of lipid homeostasis in the central nervous system. Lipids are essential components of cell membranes and are crucial for neuronal function. Disruptions in lipid metabolism have been implicated in numerous neurological disorders, including Alzheimer's disease and Parkinson's disease. ABCA4 has been found to interact with other proteins involved in synaptic transmission and neuronal signaling. This suggests that the protein may play a role in modulating communication between neurons, which is essential for cognitive function.

Product Specifications

Specifications

Immunofluorescence: 10 µg/mL, ELISA (peptide) LOD: 1:128000

UniProt

P16284

Host

Goat

Reactivity

Human, Mouse

Immunogen

Amino acids KQQTESHDLPLHPR were used as the immunogen for this ABCA4 antibody.

Clonality

Polyclonal

Isotype

Ig

Applications

IF, ELISA (peptide)

Purity

Antigen affinity

Format

Antigen affinity purified

Limitations

This ABCA4 antibody is available for research use only.

Storage Conditions

Aliquot and store the ABCA4 antibody at -20°C.

Formulation

0.5 mg/mL in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide

Applications Notes

Optimal dilution of the ABCA4 antibody should be determined by the researcher.

Location

Membrane, ER, Cytoplasmic vesicles

Image Legend

Immunofluorescent staining of fixed and permeabilized human HeLa cells with ABCA4 antibody (green) at 10ug/ml and DAPI nuclear stain (blue) .

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