Ch-TOG Antibody / CKAP5
Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is mapped to 11p11.2. This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement.
Product Specifications
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Immunocytochemistry/Immunofluorescence: 2-4 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q14008
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids M1-L221 from the human protein were used as the immunogen for the Ch-TOG antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC/IF, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Limitations
This Ch-TOG antibody is available for research use only.
Storage Conditions
Store the Ch-TOG antibody at -20°C.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Ch-TOG antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of human 1) K562, 2) HL60, 3) HEK293 and 4) PC-3 cell lysate with Ch-TOG antibody. Predicted molecular weight ~225 kDa.
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