KCNH2 Antibody / ERG-1
KCNH2, also known as HERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr) ) that conducts potassium (K+) ions out of the muscle cells of the heart (cardiac myocytes), and this current is critical in correctly timing the return to the resting state (repolarization) of the cell membrane during the cardiac action potential.
Product Specifications
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q12809
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids R159-A223 from the human protein were used as the immunogen for the KCNH2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Limitations
This KCNH2 antibody is available for research use only.
Storage Conditions
Store the KCNH2 antibody at -20°C.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the KCNH2 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) K562 and 2) U-2 OS cell lysate with KCNH2 antibody. Expected molecular weight: 127-155 kDa.
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