TRIP10 Antibody / CIP4
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. [UniProt]
Product Specifications
Specifications
Western blot: 1:500-1:2000
UniProt
Q15642
Host
Rabbit
Reactivity
Human
Immunogen
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
28T70
Applications
WB
Purity
Affinity chromatography
Format
Purified
Limitations
This TRIP10 antibody is available for research use only.
Storage Conditions
Store the TRIP10 antibody at -20°C.
Product Datasheet
https://www.nsjbio.com/tds-pdf/trip10-antibody-cip4-28t70-rq8543
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the TRIP10 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HepG2 cell lysate with TRIP10 antibody. Expected molecular weight: 40-85 kDa (multiple isoforms) .
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