UBA3 Antibody / Ubiquitin-activating enzyme 3 / UBE1C
NEDD8-activating enzyme E1 catalytic subunit (UBA3) is the catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. [UniProt]
Product Specifications
Specifications
Western blot: 1:500-1:2000
UniProt
Q8TBC4
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide from human NEDD8-activating enzyme E1 catalytic subunit protein was used as the immunogen for the UBA3 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
28U91
Applications
WB
Purity
Affinity chromatography
Format
Purified
Limitations
This UBA3 antibody is available for research use only.
Storage Conditions
Store the UBA3 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the UBA3 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with UBA3 antibody. Predicted molecular weight ~52 kDa.
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