MANSC1 Antibody / MANSC domain-containing protein 1

MANSC1 (MANSC domain-containing protein 1), also known as LOH12CR3 (Loss of heterozygosity 12 chromosomal region 3 protein), is a 414 amino acid single-pass membrane protein. Expressed throughout the body, MANSC1 contains one MANSC domain and is encoded by a gene that is located on chromosome 12. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction.

Product Specifications

Specifications

Western blot: 0.5-1 µg/mL, ELISA: 0.1-0.5 µg/mL

UniProt

Q9H8J5

Host

Rabbit

Reactivity

Human

Immunogen

An E.coli-derived human recombinant protein (amino acids L21-N337) was used as the immunogen for the MANSC1 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, ELISA

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose

Limitations

This MANSC1 antibody is available for research use only.

Storage Conditions

After reconstitution, the MANSC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the MANSC1 antibody should be determined by the researcher.

Image Legend

Western blot testing of human 1) RT4 and 2) U-251 cell lysate with MANSC1 antibody. Predicted molecular weight ~47 kDa but may be observed at higher molecular weights due to glycosylation.