Interferon regulatory factor 4 Antibody / IRF4 / MUM1
Interferon regulatory factor 4 (IRF4), also known as Multiple myeloma oncogene 1 (MUM1), is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.
Product Specifications
Specifications
Western blot: 1-2 µg/mL, Immunofluorescence: 5 µg/mL, ELISA: 0.1-0.5 µg/mL
UniProt
Q15306
Host
Rabbit
Reactivity
Human
Immunogen
An E.coli-derived human recombinant protein (amino acids A163-Q419) was used as the immunogen for the Interferon regulatory factor 4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, ELISA
Purity
Antigen affinity chromatography
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Limitations
This Interferon regulatory factor 4 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Interferon regulatory factor 4 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Frequently Asked Questions
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