ST15 Antibody / RECK / Suppressor of tumorigenicity 15

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK and Suppressor of tumorigenicity 15 (ST15), is a human gene, thought to be a metastasis suppressor. The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene.