ACAT1 Antibody / Acetyl-CoA acetyltransferase

The Acetyl-CoA acetyltransferase protein, also called ACAT1, is an enzyme that catalyzes the conversion of Acetyl-CoA to acetoacetyl-CoA. This reaction is a key step in the fatty acid beta-oxidation pathway, which is essential for the breakdown of fatty acids and the production of energy. Additionally, ACAT1 plays a critical role in ketogenesis, a process that occurs during times of fasting or low carbohydrate intake. The structure of the Acetyl-CoA acetyltransferase protein is highly conserved among different species, indicating its importance in cellular metabolism. This enzyme contains an active site where the catalytic reaction takes place, as well as binding sites for its substrate and cofactors. The precise mechanism by which Acetyl-CoA is converted to acetoacetyl-CoA by this enzyme involves a series of chemical reactions that involve the transfer of acetyl groups.