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Alpha-Synuclein Antibody / SNCA

Mutations or abnormal accumulation of Alpha-Synuclein are strongly linked to synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Its aggregation into insoluble fibrils is a key pathological hallmark of these conditions. Studying Alpha-Synuclein expression and distribution provides valuable insights into neuronal function, protein misfolding, and neurodegenerative disease mechanisms. Using a high-quality Alpha-Synuclein antibody enables sensitive detection in assays such as western blot, immunohistochemistry, and ELISA. An Alpha-Synuclein antibody from NSJ Bioreagents offers reliable performance for researchers investigating protein aggregation, neurodegenerative disease progression, and potential therapeutic interventions. Selecting the appropriate Alpha-Synuclein antibody is essential for generating reproducible and accurate results in both basic and applied neuroscience research.

Product Specifications

Specifications

Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200, Immunofluorescence: 1:50-1:200

UniProt

P37840

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide sequence specific to Alpha-Synuclein was used as the immunogen for the Alpha-Synuclein antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG

Clone

AGA-19

Applications

WB, IF, IHC-P

Purity

Affinity chromatography

Format

Purified

Limitations

This Alpha-Synuclein antibody is available for research use only.

Storage Conditions

After reconstitution, the Alpha-Synuclein antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

Applications Notes

Optimal dilution of the Alpha-Synuclein antibody should be determined by the researcher.

Location

Nuclear, cytoplasmic, cell membrane

Image Legend

IHC staining of FFPE human colon cancer tissue with Alpha-Synuclein antibody, HRP-secondary and DAB substrate. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
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