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POLG Antibody / DNA polymerase subunit gamma 1

Mutations in POLG are associated with a range of mitochondrial disorders, including progressive external ophthalmoplegia, Alpers-Huttenlocher syndrome, and ataxia-neuropathy syndromes. Studying POLG function helps researchers understand mitochondrial genome maintenance and the molecular basis of mitochondrial diseases. Using a high-quality POLG antibody allows for sensitive detection of the protein in assays such as western blot, immunohistochemistry, and immunofluorescence. A POLG antibody from NSJ Bioreagents offers consistent performance, supporting studies in mitochondrial biology, genetic disorders, and DNA repair mechanisms. Choosing the right POLG antibody is critical for producing reliable and reproducible research results.

Product Specifications

Specifications

Western blot: 1:500-1:2000

UniProt

P54098

Host

Rabbit

Reactivity

Human

Immunogen

A peptide sequence specific to DNA polymerase subunit gamma 1 was used as the immunogen for the POLG antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG

Clone

24P93

Applications

WB

Purity

Affinity chromatography

Format

Purified

Limitations

This POLG antibody is available for research use only.

Storage Conditions

After reconstitution, the POLG antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

Applications Notes

Optimal dilution of the POLG antibody should be determined by the researcher.

Image Legend

Western blot testing of human 1) MCF7, 2) Jurkat and 3) SiHa cell lysate with POLG antibody. Predicted molecular weight ~140 kDa.

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