Zebrafish Cdk5 Antibody
CDK5, Cyclin-Dependent Kinase 5, is also known as PSSALRE. The p34 (CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35 (CDK5R1) . CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.
Product Specifications
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q9DE44
Host
Rabbit
Reactivity
Zebrafish
Immunogen
An E.coli-derived zebrafish Cdk5 recombinant protein (amino acids M1-Q226) was used as the immunogen for the Zebrafish Cdk5 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity chromatography
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Limitations
This Zebrafish Cdk5 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Zebrafish Cdk5 antibody should be determined by the researcher.
Image Legend
Western blot analysis of Cdk5 protein using Cdk5 antibody and zebrafish embryo tissue lysate. The predicted molecular weight of Cdk5 is ~33 kDa.
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