Zebrafish Cdk5 Antibody

CDK5, Cyclin-Dependent Kinase 5, is also known as PSSALRE. The p34 (CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35 (CDK5R1) . CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.

Product Specifications

Specifications

Western blot: 0.5-1 µg/mL

UniProt

Q9DE44

Host

Rabbit

Reactivity

Zebrafish

Immunogen

An E.coli-derived zebrafish Cdk5 recombinant protein (amino acids M1-Q226) was used as the immunogen for the Zebrafish Cdk5 antibody.

Clonality

Polyclonal

Isotype

Applications

Purity

Antigen affinity chromatography

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose

Limitations

This Zebrafish Cdk5 antibody is available for research use only.

Storage Conditions

After reconstitution, the Zebrafish Cdk5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.